Selective accumulation of biotin in arterial chemoreceptors: requirement for carotid body exocytotic dopamine secretion
نویسندگان
چکیده
منابع مشابه
The role of NADPH oxidase in carotid body arterial chemoreceptors.
O(2)-sensing in the carotid body occurs in neuroectoderm-derived type I glomus cells where hypoxia elicits a complex chemotransduction cascade involving membrane depolarization, Ca(2+) entry and the release of excitatory neurotransmitters. Efforts to understand the exquisite O(2)-sensitivity of these cells currently focus on the coupling between local P(O2) and the open-closed state of K(+)-cha...
متن کاملOxygen sensing by the carotid body chemoreceptors.
Carotid bodies are sensory organs that detect changes in arterial blood oxygen, and the ensuing reflexes are critical for maintaining homeostasis during hypoxemia. During the past decade, tremendous progress has been made toward understanding the cellular mechanisms underlying oxygen sensing at the carotid body. The purpose of this minireview is to highlight some recent concepts on sensory tran...
متن کاملHypoxia transduction by carotid body chemoreceptors in mice lacking dopamine D(2) receptors.
Hypoxia-induced dopamine (DA) release from carotid body (CB) glomus cells and activation of postsynaptic D(2) receptors have been proposed to play an important role in the neurotransmission process between the glomus cells and afferent nerve endings. To better resolve the role of D(2) receptors, we examined afferent nerve activity, catecholamine content and release, and ventilation of genetical...
متن کامل[Arterial chemoreceptors: cellular and molecular mechanisms in the adaptative and homeostatic function of the carotid body].
The carotid body is a sensory chemoreceptor organ located in the vicinity of the carotid bifurcation. Structurally it is composed of cell clusters formed by chemoreceptor and supporting cells. The sensory nerve endings of the carotid sinus nerve penetrate the clusters to synapse with chemoreceptor cells. The carotid body plays an important role in the control of ventilation during hypoxia, hype...
متن کاملStimulation of the carotid chemoreceptors of the dog by dopamine.
The mechanisms by which chemosensitive receptors in the carotid body are activated by the changes in the Po2, Pco,, or pH of arterial blood or by a variety of chemicals are still unknown. Physiological activation may require the release of a transmitter substance, formed or stored in Type I chemoreceptor cells, which then excites contiguous sensory nerve endings. Recently, a number of investiga...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2016
ISSN: 0022-3751
DOI: 10.1113/jp272961